Abstracts
Programme at a glance
   

Thursday  Friday   Saturday  Sunday  Monday

SYMPOSIUM 1

OSTEOBLASTS

Chairs: R. Civitelli (St. Louis MO, USA)
P. Marie (Paris, France)

09:00 I-2 Role of the Wnt/LRP5 pathway in regulation of bone mass and osteoblast function
M. Warman (Cleveland OH, USA)

09:30 I-3 The transcription factor osterix is required for osteoblast differentiation and bone formation
B. de Crombrugghe (Houston TX, USA)

ORAL COMMUNICATIONS

OSTEOBLASTS 1

10:00 - 11:00 Main Auditorium

10:00 O-1SIGNALING VIA BETA-CATENIN DIRECTS MESENCHYMAL LINEAGE ALLOCATION TOWARDS OSTEOGENESIS
G. Mbalaviele^1,2, S. Sheikh¹, C. Castro¹, S-L. Cheng¹, J. Stains¹, R. Civitelli¹*
¹Div. of Bone and Mineral Diseases, Washington University in St. Louis, Missouri, USA
²Pharmacia Corp., St. Louis, Missouri, USA

10:12 O-2 FUNCTIONAL ROLE OF CANONICAL WNT SIGNALLING DURING OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS

S. L. Etheridge¹*, G. J. Spencer¹, D. Heath², P. G. Genever^1
1Biomedical Tissue Research, University of York, York, UK
²Smith and Nephew GRC, York, UK

10:24 O-3 PLATELET-DERIVED GROWTH FACTOR-D, A NOVEL BONE-ANABOLIC GROWTH FACTOR
S. Topouzis*, K. Lum, M. S. Holdren, J. Shin, C. Birks, D. Dong, S. D. Hughes, H. P. Ren, T. Palmer, E. E. Moore
ZymoGenetics Inc., Seattle, USA

10:36 O-4 GENETIC ABLATION OF PROLINE-RICH TRANSCRIPT OF THE BRAIN IS ASSOCIATED WITH INCREASED BONE MASS IN MICE
D. W. Sommerfeldt¹*, M. Priemel¹, X. Wang², T. Schinke¹, M. Amling¹, S. Mansour², J. M. Rueger^1
1Dept. of Trauma and Reconstructive Surgery, Hamburg University Hospital, Hamburg, Germany
²Dept. of Human Genetics, University of Utah, Salt Lake City, USA

10:48 O-5 DLK1 (EGF-LIKE HOMEOTIC PROTEIN) OVEREXPRESSION INHIBITS MATURE ADIPOCYTE AND OSTEOBLAST FORMATION AND MAINTAINS THE BIOPOTENTIAL DIFFERENTIATION CAPACITY OF HUMAN BONE MARROW STROMAL CELLS
B. M. Abdallah¹*, C. H. Jensen², G. Leslie², T. B. Jensen³, M. Kassem^1,4
1Clinic for Molecular Endocrine Treatment KMEB, Odense University Hospital, Odense, Denmark
²Institute of Medical Immunology, Univeristy of Southern Denmark, Odense, Denmark
³Department of Human Genetics, University of Aarhus, Aarhus, Denmark
⁴Dept of Endocrinology M, Odense University Hospital, Odense, Denmark

11:00 - 12:00 Coffee & Posters

12:00 - 14:00 Lunch

WORKSHOP 1

NANOTECHNOLOGY

Chairs: P. Bianco (Rome, Italy)
K. Väänänen (Turku, Finland)

12:45 - 14:00 Room A

12:45 I-4 Nanotechnology - where biology meets physics
W. Poon (Edinburgh, UK)

13:10 I-5 Probing bone cell function with AFM
M. A. Horton (London, UK)

13:35 I-6 Nanotechnology of collagen and bone: interaction and structure
P. K. Hansma (Santa Barbara, USA)

WORKSHOP 2

Chairs: D. Dempster (New York NY, USA)
G. Mazzuoli (Rome, Italy)

12:45 - 14:00 Main Auditorium

12:45 I-7 How do we assess bone quality?
C. H. Turner (Indianapolis, USA)

13:10 I-8 Role of bone turnover in bone quality
P. Delmas (Lyon, France)

13:35 I-9 Importance of mineralization for bone strength and response to therapeutic agents
P. J. Meunier (Lyon, France)

SYMPOSIUM 2

Chairs: G. Isaia (Torino, Italy)
B. Langdahl (Aarhus, Denmark)

14:00 - 15:00 Main Auditorium

14:00 I-10 Modulation of estrogen action by ER isoforms
J-Å. Gustafsson (Huddinge, Sweden)

14:30 I-11 Risks and benefits of HRT and SERMS
E. Barrett-Connor (La Jolla, California, USA)

ORAL COMMUNICATIONS

Chairs: G. Isaia (Torin, Italy)
B. Langdahl (Aarhus, Denmark)

15:00 - 16:00 Main Auditorium

15:00 O-6 SKELETAL CHANGES IN TRANSGENIC MALE MICE OVEREXPRESSING HUMAN AROMATASE
Z. Q. Peng¹*, X. D. Li², M. Poutanen², R. Santti¹, H. K. Väänänen^1
1Dept. of Anatomy, Univ. of Turku, Finland
²Dept. of Physiology, Univ. of Turku, Finland

15:12 O-7 RALOXIFENE INCREASES SERUM ESTRADIOL AND TESTOSTERONE AND DECREASES BIOCHEMICAL MARKERS OF BONE TURNOVER IN MIDDLE AGED HEALTHY MEN WITH LOW BASELINE SEX STEROID SERUM VALUES
B. Uebelhart¹*, F. Herrmann², I. Pavo³, R. Rizzoli^1
1Division of Bone Diseases, University Hospital, Geneva, Switzerland
²Department of Geriatrics, University Hospital, Geneva, Switzerland
³Eli Lilly, Vienna, Austria

15:24 O-8 SHORT COURSES OF HORMONE REPLACEMENT TREATMENT IN HEALTHY WOMEN HAVE LONG-TERM PREVENTIVE EFFECTS ON BONE MASS AND OSTEOPOROTIC FRACTURES
Y. Z. Bagger*, L. B. Tanko, P. Alexandersen, C. Christiansen
Center for Clinical and Basic Research, Ballerup, Denmark

15:36 O-9 POLYMORPHISMS IN THE CYP19 AND ANDROGEN RECEPTOR GENES AND BONE MASS IN WOMEN WITH OR WITHOUT HORMONE REPLACEMENT THERAPY. THE DANISH OSTEOPOROSIS PREVENTION STUDY
C. L. Tofteng¹*, A. Kindmark², H. Brandstrom², B. Abrahamsen³, S. Petersen¹, F. Stiger², L. S. Stilgren³, J. E. B. Jensen¹, P. Vestergaard, B. I. Langdahl⁴, L. Mosekilde^4
1Osteoporosis Research Clinic, Hvidovre Hospital, Hvidovre, Denmark
²Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
³Department of Endocrinology, Odense University Hospital, Odense, Denmark
⁴Department of Endocrinology, Aarhus County Hospital, Aarhus, Denmark

15:48 O-10 GENDER DIFFERENCES IN ASSOCIATION OF 5' ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISMS WITH BONE PARAMETERS, HEIGHT AND FRACTURE RISK
S. C. E. Schuit^1,2*, J. B. J. van Meurs^1,2, A. E. A. M. Weel¹, M. van der Klift², A. P. Bergink^1,2, Y. Fang¹, P. P. Arp¹, J. P. T. M. van Leeuwen¹, H. A. P. Pols^1,2, A. G. Uitterlinden^1
1Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
²Department of Epidemiology & Biostatistics, Erasmus MC, Rotterdam, The Netherlands

16:00 - 16:20 Coffee

Chairs: E. Bonucci (Rome, Italy)
H. van Leeuwen (Rotterdam, Netherlands)

16:20 - 17:20 Main Auditorium

16:20 O-11 NEW INSIGHTS INTO CALCINEURIN ALPHA FUNCTION AND SIGNALING
E. Abe¹, X. B. Wu¹, M. Lu¹, X. Zhang¹, B. S. Moonga¹, S. Epstein¹, H. C. Blair², L. Sun¹, M. Zaidi¹*
¹The Mount Sinai Bone Program and Bronx VA GRECC, New York, NY. USA
²University of Pittsburgh, Pittsburgh, PA. USA

16:32 O-12 WNT-MEDIATED TCF GENE TRANSCRIPTION IN OSTEOBLASTS: A NOVEL EFFECTOR OF OSTEOTROPIC HORMONES AND CYTOKINES?
G. J. Spencer*, S. L. Etheridge, P. G. Genever
Biomedical Tissue Research, University of York, York, UK

16:44 O-13FIBROBLAST GROWTH FACTOR-2 ENHANCES HUMAN OSTEOBLAST SURVIVAL THROUGH ACTIVATION OF THE PI3K AND GSK-3 SIGNALING PATHWAY
F. Debiais¹*, S. Lemée¹, G. Lefèvre², F. Mascarelli², P. J. Marie^1
1Inserm U349, Paris, France
²Inserm U403, Paris, France

16:56 O-14 ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA INHIBITS THE RUNX2-MEDIATED TRANSCRIPTION OF OSTEOCALCIN IN OSTEOBLASTS
C. S. Shin^1,2*, M. J. Jeon², S. H. Kwon¹, J. A. Kim², S. W. Kim¹, S. Y. Kim^1,2
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
²Seoul National University Hospital Clinical Research Institute, Seoul, Korea

17:08 O-15 IDENTIFICATION OF TWO EPITHELIAL CALCIUM CHANNELS, TRPV5 AND 6, ALONG WITH OTHER PROTEINS INVOLVED IN CALCIUM TRANSPORT IN HUMAN OSTEOBLASTS, IN VITRO AND VIVO
B. C. J. van der Eerden¹*, M. Eijken¹, H. Jahr^1,2, J. G. J. Hoenderop³, H. A. P. Pols¹, R. J. M. Bindels³, J. P. T. M. van Leeuwen^1
1Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
²Department of Orthopedics, Erasmus MC, Rotterdam, The Netherlands
³Department of Cell Physiology, University Medical Center, Nijmegen, The Netherlands

17:20 - 17:40 Coffee

Supported by Eli Lilly & Co

Chair: S. Adami

17:40 - 19:40 Main Auditorium

A brief Question & Answer session will follow each presentation.

17:40 -17:50 Opening Remarks
Silvano Adami

17:50 -18:25 Bone Quality: Shifting the
Osteoporosis Paradigm
Ego Seeman

18:25 -19:00 The Role of Antiresorptive Agents on Bone Quality
Pierre Delmas

19:00 -19:35 Innovative Effects of Bone Formation Agents on Bone Quality
David Dempster

20:00 ECTS COPPA ITALIA FOOTBALL