IBMS/ECTS 2001 - PROGRAM and ABSTRACTS

BONE CELL BIOLOGY

Chairs: Roland Baron (New Haven, CT/USA),
Jesus González Macías (Santander/Spain),
Anna Teti (L'Aquila/Italy)

11:30 SC1 W

IDENTIFICATION OF A BISPHOSPHONATE WHICH INHIBITS FPP SYNTHASE AND IPP ISOMERASE

K. Thompson*, F. P. Coxon, J. E. Dunford, F. H. Ebetino, M. J. Rogers

Department of Medicine and Therapeutics, University of Aberdeen, UK; Procter & Gamble Pharmaceuticals, Cincinnati, USA

11:35 SC2 W

IDENTIFICATION OF A PHOSPHONOCARBOXYLATE ANALOGUE OF RISEDRONATE WHICH INHIBITS GERANYLGERANYL TRANSFERASE II AND SELECTIVELY PREVENTS PRENYLATION OF RAB PROTEINS IN OSTEOCLASTS

F. P. Coxon*, B. Larijani, J. E. Dunford, M. C. Seabra, F. H. Ebetino, S. P. Luckman, M. J. Rogers

University of Aberdeen, UK; Imperial College London, UK; Procter & Gamble Pharmaceuticals, Cincinnati, USA

11:40 SC3 W

ANDROGENS AND ESTROGENS SUPPRESS RANKL-INDUCED OSTEOCLAST FORMATION VIA A DIRECT ACTION ON OSTEOCLAST PRECURSORS

J. W. Pike*, A. C. Bendixen, D. M. Huber, K. M. Dienger, S. Srivastava, P. Pathrose, N. K. Shevde

University of Cincinnati, Cincinnati, Ohio, USA

11:45 SC4 W

HUMAN OSTEOPROTEGERIN STIMULATES METALLOPROTEINASE ACTIVITIES OF RABBIT BONE CELLS BY THE RAS/MAPK PATHWAY

A. V. Rousselle*, E. Grimaud, Y. Fortun, M. Padrines, F. Redini, D. Heymann

Medicine Faculty, EE-99/01, Nantes, France

11:50 SC5 W

ANTI-RESORPTIVE AND SURVIVAL ACTIONS OF SELECTIVE INTEGRIN PEPTIDOMIMETICS ON AUTHENTIC HUMAN OSTEOCLASTS

P. Collin-Osdoby*, F. Anderson, L. Rothe, X. Yu, M. Nelson, Y. Huang, W. Maloney, W. Westlin, G. A. Nickols, P. Osdoby

Washington Unviversity, USA; Pharmacia, USA

11:55 SC6 W

DISCOVERY AND ANALYSIS OF OSTEOBLAST RELATED GENES USING CDNA MICROARRAY

A. Raouf, A. Seth*

Department of Laboratory Medicine & Pathobiology, University of Toronto, Canada; CIHR group in Periodontal Physiology, University of Toronto, Canada; Laboratory of Molecular Pathology, Sunnybrook and Women's College Health Sciences Centre

12:00 SC7 W

IN VIVO EVIDENCE FOR ESTRADIOL-CONTROLLED INSULIN-LIKE GROWTH FACTOR-I AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-5 EXPRESSION IN BONE CELLS

E. M. Colin, D. J. Lindenbergh-Kortleve, G. J. C. M. van den Bemd, C. J. Buurman, J. W. van Neck, S. L. S. Drop, H. A. P. Pols, J. P. T. M. van Leeuwen*

Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus Medical Center Rotterdam, The Netherlands

12:05 SC8 W

PROTEIN KINASE C-DEPENDENT UP-REGULATION OF N-CADHERIN EXPRESSION BY PHORBOL ESTER IN HUMAN OSTEOBLASTS

P. Delannoy, J. Lemonnier, E. Hay, D. Modrowski, P. J. Marie*

INSERM U349, Hopital Lariboisiere, Paris, France

12:10 SC9 W

ACTIVATION OF THE PROTEIN KINASE B (PKB/AKT) SIGNALLING PATHWAY IN OSTEOBLASTS BY MECHANICAL STRAIN

T. S. Grewal*, R. J. Tolley, T. M. Skerry

Department of Biology, University of York, York, UK

12:15 SC10 W

C-SRC AND PKC ISOFORMS REGULATE OSTEOBLAST DIFFERENTIATION

S. Migliaccio*, M. Marzia, N. Sims, A. Taranta, S. Bernardini, R. Baron, A. Teti

Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy; Department of Experimental Medicine, University "La Sapienza", Rome, Italy; Department of Cell Biology and Orthopaedics, Yale University, New Haven, USA; Istituto Dermopatico dell'Immacolata, Rome, Italy

12:20 SC11 W

ANALYSIS OF THE MURINE MODEL OF THE SAETHRE-CHOTZEN SYNDROME SUGGESTS A FUNCTIONAL RELATIONSHIP BETWEEN TWIST AND FGFR2

V. El Ghouzzi*, R. Quillet, C. Stoetzel, A. Munnich, J. Bonaventure, F. Perrin-Schmitt

INSERM U393, Hôpital Necker, Paris, France; LGME-CNRS/INSERM U184, Faculté de Médecine, Strasbourg, France

All Short Communications will be displayed as posters throughout the conference. Those presented in this session will be attended during Poster Session 1 which follows.

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