IBMS/ECTS 2001 - PROGRAM and ABSTRACTS

CELL BIOLOGY: OSTEOBLASTS AND RELATED CYTOKINES

Chairs: Roberto Civitelli (St. Louis, MO/USA),
Slobodan Vukicevic (Zagreb/Croatia)

Thursday, June 7, 2001
08:30 - 09:30 Auditorium

IN6

Osteoblastic Control of Bone Formation

Patricia Ducy (Houston, TX/USA)

IN7

Osteoblast Apoptosis and the Regulation of Bone Formation

Robert L. Jilka (Little Rock, AR/USA)

[Thursday at a Glance]   [Contents page]

ORAL PRESENTATIONS 3

CELL BIOLOGY: OSTEOBLASTS AND RELATED CYTOKINES

Chairs: Roberto Civitelli (St. Louis, MO/USA),
Slobodan Vukicevic (Zagreb/Croatia)

Thursday, 7 June, 2001
09:30 - 11:10 Auditorium

The abstract text of oral presentations (prefix OR) can be found in the Abstracts section.

09:30 OR19

PROTEASOME INHIBITORS STIMULATE OSTEOBLAST DIFFERENTIATION AND BONE FORMATION BY INHIBITING GLI3 DEGRADATION AND ENHANCING BMP-2 EXPRESSION

D. Chen*, I. R. Garrett, M. Qiao, G. Rossini, M. Zhao, Z. Mi, C. M. Crews, S. Ishii, G. R. Mundy

University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA; OsteoScreen Inc., San Antonio, Texas, USA; Yale University, New Haven, Connecticut, USA; RIKEN Tsukuba Institute, Tsukuba, Ibaraki, Japan

09:42 OR20

REGULATION OF OSTEOBLAST DIFFERENTIATION IN VITRO BY THE DELTAFOSB FAMILY OF TRANSCRIPTION FACTORS

G. Sabatakos*, M. Wu, G. Rawadi, S. Roman-Roman, R. Baron

Yale University, USA; Aventis, France

09:54 OR21

RETROVIRAL BMP4 STIMULATES OSTEOGENIC DIFFERENTIATION OF MUSCLE-DERIVED STEM CELLS AND INDUCES DE NOVO BONE FORMATION: POTENTIAL FOR BONE GENE THERAPY

V. Wright, H. Peng*, A. Usas, J. Huard

University of Pittsburgh Department of Orthopaedic Surgery, Pittsburgh, PA, USA

10:06 OR22

STATINS MEDIATE BONE FORMATION BY ENHANCING BMP2 EXPRESSION

I. R. Garrett*, D. Chen, M. Zhao, G. Gutierrez, A. Escobedo, D. Horn, J. Esparza, G. R. Mundy

OsteoScreen Inc., San Antonio, Texas, USA; University of Texas Health Science Center at San Antonio, Texas, USA

10:18 OR23

INACTIVATION OF GLUCOCORTICOIDS IN OSTEOBLASTS BY TARGETED OVEREXPRESSION OF 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 2 IN TRANSGENIC MICE

H. W. Woitge*, I. Kalajzic, S. H. Clark, G. Gronowicz, Z. Krozowski, J. R. Harrison, B. E. Kream

Department of Medicine I, University of Heidelberg, Heidelberg, Germany; Department of Medicine, University of Connecticut Health Center, Farmington, USA; Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, USA; Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, USA; Laboratory of Molecular Hypertension, Baker Medical Research Institute, Prahran, Australia

10:30 OR24

THE NMDA-TYPE GLUTAMATE RECEPTOR ANTAGONIST MK801 REGULATES DIFFERENTIATION OF NON-ADHERENT RAT BONE MARROW OSTEOPROGENITORS

K. R. Dobson*, T. M. Skerry

University of York, York, UK

10:42 OR25

CORTICAL BONE RESORPTION IS DRAMATICALLY INCREASED IN ADULT MICE OVEREXPRESSING OSF2/CBFA1 IN OSTEOBLASTS UNDER THE CONTROL OF COLLAGEN TYPE I

M. Kneissel*, A. Boyde, B. Fournier, P. Matthias, V. Geoffroy

Novartis Pharma AG, Basle, Switzerland; University College London, London, UK; Friedrich Miescher Institute, Basle, Switzerland

10:54 OR26

IDENTIFICATION OF A UNIQUE POPULATION OF BONE MORPHOGENETIC PROTEIN-6-EXPRESSING CELLS DURING OSTEOGENESIS IN VIVO

A. Plant*, J. H. Tobias

Rheumatology Unit, Division of Medicine, University of Bristol, Bristol, UK

[Thursday at a Glance]  [Contents page]