|
Meet
the
Professor
Sessions
Jane
Lian
(Worcester,
USA)
Regulation
of
osteoblasts
and
metastatic
cells
by
Runx2
Topics
to
be
covered
-
The
onset
and
maturation
of
bone
formation
in
the
developing
skeleton
is
regulated
by
many
signaling
pathways
that
are
transduced
to
cellular
intermediates
that
are
further
regulated
by
post-transcriptional
mechanisms
and
interact
with
transcription
factors
to
support
gene
expression.
- Runx2
is
an
essential
transcription
factor
for
bone
formation
and
integrates
the
activities
of
several
signalling
pathways
operative
in
normal
osteoblast
lineage
cells
as
well
as
breast
and
prostate
cancer
cell
that
metastatic
to
bone
-
This
MTP
session
will
compare
and
contrast
Runx2
activities
between
osteoblasts
and
tumor
cells
-
While
numerous
therapeutics
are
available
for
treating
bone
disorders,
recent
discoveries
of
control
mechanisms
for
osteblastogenesis
and
bone
formation
pave
the
way
for
even
better
opportunities
to
regenerate
bone
tissue
accompanying
metastatic
bone
disease
Educational
goals
After
attending
this
Meet
the
Professor
session,
participants
will
be
expected
to:
- understand
how
developmental
and
ECM
signaling
pathways
transduce
their
effects
in
osteoblasts
and
tumor
cells
through
Runx2
- understand
how
co-regulatory
protein
interactions
with
transcription
factors
to
modify
positive
and
negative
regulation
of
gene
expression
-
be
able
to
evaluate
how
current
tumor
therapies
affect
the
skeleton
through
Runx2
Target
audience
-
Graduate
students,
post-doctoral
trainees
,
as
well
as
established
investigators
and
physician
scientists
Teaching
methods
- Handouts
and
a
few
slides
-
Addressing
audience
questions
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