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Meet
the
Professor
Sessions
Claus
Glüer
(Kiel,
Germany)
The
use
of
bone
imaging
in
clinical
trials
of
osteoporosis
drugs
Topics
to
be
covered
- Most
drug
studies
have
employed
Dual
X-Ray
Absorptiometry
(DXA)
as
imaging
technique
to
assess
treatment
efficacy
-
Recently
subsets
of
patients
have
also
been
evaluated
by
Quantitative
Computed
Tomography
(QCT)
for
which
there
are
different
approaches
depending
on
whether
it
is
applied
for
measurements
at
the
spine,
the
proximal
femur
or
at
peripheral
sites
like
the
radius
and
the
tibia
and
whether
it
is
used
to
study
bone
mineral
density
(standard
QCT)
or
bone
micro-structure
(high
resolution
CT)
-
Alternatively,
Quantitative
Ultrasound
methods
can
be
applied
-
This
session
will
highlight
the
differences
of
these
approaches
and
also
put
them
in
perspective
with
laboratory
assessments.
The
following
topics
will
be
covered:
-
Advantages
and
limitations
of
DXA
-
Advantages
and
limitations
of
QCT
-
Advantages
and
limitations
of
QUS
-
Role
of
imaging
and
bone
turnover
markers
Educational
goals
After
attending
this
Meet
the
Professor
session,
participants
will
be
expected
to:
-
understand
technological
differences
of
DXA,
QCT,
and
QUS
-
understand
respective
strengths
and
weaknesses
of
central
and
peripheral
measurements
-
understand
respective
strengths
and
weaknesses
of
imaging
and
laboratory
markers
-
understand
goals
for
future
developments
Target
audience
-
Researchers
interested
in
imaging
studies
on
treatment
effects
-
Clinicians
involved
in
innovative
clinical
trials
that
encompass
advanced
imaging
approaches
-
Clinicians
interested
to
find
out
whether
QCT
approaches
(and
which
QCT
approaches)
might
provide
information
on
bone
status
beyond
that
available
from
DXA
measurements
Teaching
methods
-
Develop
list
of
key
requirements
for
imaging
techniques
together
with
participants
-
Generate
table
on
flip
chart
with
strength
and
limitations
of
the
various
approaches
-
Discuss
experience
and
needs
of
participants
with
regard
to
new
imaging
approaches
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