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Meet the Professor
André Uitterlinden
Complex Genetics: study design and genotyping
techniques
Outline of topics
Genetic analysis of complex diseases such as osteoporosis,
has made substantial progress through accomplishments of the Human Genome
project and its sequela (dbSNP, HapMap), novel technological developments,
changes in study designs and importantly collaborative efforts. The most
recent ones are the combination of the Genome Wide Association (GWA) approach
with formation of large consortia of investigators. This combined approach
has been highly successful in several complex diseases including for osteoporosis
for which several risk loci have now been identified. This workshop will
address approaches, pitfalls and progress in identifying genetic markers
for bone diseases such as osteoporosis.
Topics to be covered
- Study design and data analysis (collections, populations, consortia,
meta-analysis)
- Genotyping techniques (single SNPs, Genome Wide Association analysis
with high density SNP arrays), DNA handling
- Examples of gene polymorphisms: associations, clinical use, functional
analysis
Educational goals
- Learn and understand principles of genetic analysis for complex traits
- Understand limitations of approaches
- Understand what approach should be taken to find risk genes for complex
traits
Target Audience
This workshop is aimed at people at all levels: medical
graduate students, basic researchers (PhD student, postdocs, staff), technicians,
clinical investigators, practising clinicians.
Teaching methods
A brief overview of the field and the topics mentioned
will be given, allowing much space for questions form the audience. The
discussion will be informal and interactive by Socratic questioning.
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