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Oral Communications
Day-at-a-glance:
Saturday Sunday
Monday Tuesday
Wednesday
Outline programme
[PDF]
Abstracts
available here
Invited
speaker abstracts
Orals 1 Orals
2 Orals 3 Orals
4 Orals 5 Orals
6 Orals 7 |
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| Sunday 25 May, 2008 |
09:00-
10:00 |
 |
Oral
Communications 1: Bone Development
Chairs: Jesus González-Macias (Santander, Spain)
Moustapha Kassem (Odense, Denmark) |
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| 09:00 |
OC01 |
LOW BONE MASS AND BLUNTED RESPONSE TO PHYSICAL EXERCISE
IN PERIOSTIN KNOCK OUT MICE
N. Bonnet*1, R. Rizzoli1, S. Ferrari1
1Department of Rehabilitation and Geriatrics, Service of
Bone Diseases, Geneva 14, Switzerland |
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| 09:12 |
OC02 |
INVOLVEMENT OF TWO MATRIX PROTEINS IN BONE HEALING:
OSTEOPONTIN AND BONE SIALOPROTEIN
L. E. MONFOULET*1, J. C. FRICAIN1, L. MALAVAL2,
J. E. AUBIN3, O. CHASSANDE1
1Biomatériaux
et réparation tissulaire, INSERM U577, Bordeaux, 2LBTO,
INSERM U890, St Etienne, France, 3Medical Genetics and
Microbiology, University of Toronto, Toronto, Canada |
|
| 09:24 |
OC03 |
THE ROLE OF RUNX1 IN SKELETAL DEVELOPMENT
R. J. van 't Hof*1, A. Liakhovitskaia2, E. Lana-Elola3,
E. Stamateris2, D. Rice3, A. Medvinski2
1Rheumatology, 2Developmental Haematopoiesis,
University of Edinburgh, Edinburgh, 3Orthodontics and Craniofacial
Development, King's College, London, United Kingdom |
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| 09:36 |
OC04 |
DLK1/FA1 IS A NOVEL MARKER FOR CHONDROCYTE DIFFERENTIATION
DURING ENDOCHONDRAL BONE DEVELOPMENT AND CHONDROGENIC LINEAGE PROGRESSION
OF HUMAN EMBRYONIC STEM CELLS
B. M. Abdallah*1, L. M. Harkness1, H. Taipaleenmaki2,
U. Frandsen1, A. Mahmood1, C. H. Jensen3,
A. Saamanen2, M. Kassem1
1Endocrinology
and Metabolism, Odense University Hospital, Odense, Denmark, 2Department
of Medical Biochemistry and Molecular Biology, University of Turku,
Turku, Finland, 3Department of Immunology and Microbiology,
University of South Denmark, Odense, Denmark |
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| 09:48 |
OC05 |
YOUNG DLX5 HETEROZYGOUS MALE MICE DEVELOP
REDUCED CORTICAL THICKNESS ASSOCIATED WITH AN INCREASE IN BONE RESORPTION
N. M. Samee*1, V. Geoffroy1, C. Marty1,
M. Vieux_Rochas2, C. Schiltz1, G. Levi2,
M. de Vernejoul1
1U606, INSERM, PARIS Cedex10, 2CNRS, UMR5166, PARIS, France
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|
15:05-
16:05 |
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Oral Communications
2: Genetics and related subjetcs
Chairs: Xavier Nogues (Barcelona, Spain)
Stuart Ralston (Edinburgh, UK) |
|
| 15:05 |
OC06 |
MUTATIONS OF SQSTM1 STRONGLY PREDICT DISEASE
SEVERITY AND COMPLICATIONS IN PAGET'S DISEASE OF BONE
M. Rios Petrakis*1, A. L. Langston2, N. Alonso3,
P. L. Selby4, W. D. Fraser5, S. H. Ralston1
1Rheumatic Diseases Unit, 2Edinburgh Clinical
Trials, University of Edinburgh, Edinburgh, United Kingdom, 3Medicine
Department, University of Salamanca, Salamanca, Spain, 4Department
of Medicine, University of Manchester, Manchester, 5Department
of Clinical Biochemistry, University of Liverpool, Liverpool, United
Kingdom |
|
| 15:17 |
OC07 |
NOVEL LOCI INFLUENCING MENOPAUSAL AGE
AND RISK FOR SURGICAL MENOPAUSE ARE IDENTIFIED BY A GENOME WIDE ASSOCIATION
STUDY
L. Stolk*1, G. Zhai2, F. Rivadeneira3,
J. B. J. van Meurs1, M. Moorhouse1, P. P. Arp1,
M. Jhamai1, A. Hofman1, H. A. P. Pols1,
J. Laven4, T. D. Spector5, A. G. Uitterlinden1
1Internal Medicine, Erasmus MC, Rotterdam, Netherlands,
2Twins Research & Genetic Epidemiology, Kings College
London, St Thomas' Hospital Campus, London, United Kingdom, 3Epidemiology,
4Gynaecology, Erasmus MC, Rotterdam, Netherlands, 5Twins
Research Unit, St Thomas Hospital Kings College, London, United Kingdom
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|
| 15:29 |
OC08 |
DOMINANT GENDER-NON-SPECIFIC DIRECT REGULATION
OF OSTEOBLASTS AND OSTEOCLASTS BY THE PITUITARY HORMONE OXYTOCIN
G. Colaianni*1, R. Tamma1, A. Di Benedetto1,
C. Camerino1, G. Greco1, N. Patano1,
M. Strippoli1, R. Vergari1, L. Sun2,
M. Zaidi2, A. Zallone1
1Human
Anatomy and Histology, University of Bari, Bari, Italy, 2Medicine
and Orthopedics, Mount Sinai School of Medicine, New York, United
States |
|
| 15:41 |
OC09 |
TRIGLYCERIDES, BMD AND PROSPECTIVE FRACTURES
IN WOMEN
P. Nordström*1, A. Nordström2, U.
Pettersson3, L. Weinehall4, G. Hallmans5,
O. Svensson6
1Department of Community Medicine
and Rehabilitation, Geriatrics, 2Department of Community
Medicine and Rehabilitation, Rehabilitation Medicine, 3Department
of Pharmacology and Clinical Neuroscience, Clinical Pharmacology,
4Department of Public Health and Clinical Medicine, Family
Medicine, 5Department of Public Health and Clinical Medicine,
Nutritional Research, 6Department of Surgical and Perioperative
Sciences, Orthopedics, Umeå, Sweden |
|
| 15:53 |
OC10 |
RELATIONSHIP BETWEEN OSTEOCALCIN AND BLOOD
GLUCOSE LEVEL IN MEN AND WOMEN– THE UFO STUDY
U. Pettersson*1, P. Nordström2, O. Svensson3,
G. Hallmans4
1Pharmacology and Clinical
Neuroscience, Clinical Pharmacology, 2Department of Community
Medicine and Rehabilitation, Geriatrics, 3Department of
Surgical and Perioperative Sciences, Orthopedics, 4Department
of Public Health and Clinical Medicine, Nutritional Research, Umeå,
Sweden |
|
| Monday 26 May, 2008 |
|
09:00-
10:00 |
|
Oral
Communications 3: Osteoporosis
Chairs: Dennis Black (San Francisco, USA)
Manuel Sosa (Las Palmas de Gran Canaria, Spain)
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|
|
| 09:00 |
OC11 |
DENOSUMAB INCREASES TOTAL, CORTICAL, AND TRABECULAR
BMD OF THE FOREARM AS MEASURED BY QCT IN POSTMENOPAUSAL WOMEN WITH
LOW BMD
H. K. Genant*1, K. Engelke2, J. P. Brown3,
M. Omizo4, H. G. Bone5, T. Fuerst2,
H. Wang6, M. Austin6, Y. Liu6, C.
Libanati6
1, UCSF and Synarc, 2,
Synarc Inc., San Francisco, CA, United States, 3CHUQ, Laval
University, Quebec, Canada, 4, Oregon Osteoporosis Ctr,
Portland, OR, 5, Michigan Bone and Mineral Clinic, Detroit,
MI, 6, Amgen Inc., Thousand Oaks, CA, United States |
|
| 09:12 |
OC12 |
THIAZOLIDINEDIONE USE AND OSTEOPOROTIC FRACTURE RISK
C. Meier*1, M. E. Kraenzlin1, M. Bodmer2,
S. S. Jick3, H. Jick3, C. R. Meier2
1Division of Endocrinology and Diabetology, 2Pharmacoepidemiology
Unit, Division of Clinical Pharmacology and Toxicology, University
Hospital, Basel, Switzerland, 3Boston Collaborative Drug
Surveillance Program, University School of Medicine, Boston, United
States |
|
| 09:24 |
OC13 |
FOR HOW MANY YEARS CAN FRACTURE BE PREDICTED BY BONE
TURNOVER MARKERS: A 7.5-YEAR FOLLOW-UP STUDY OF 1040 ELDERLY WOMEN
K. K. Ivaska*1, P. Gerdhem2, K. Väänänen1,
K. Åkesson2, K. J. Obrant2
1Department
of Anatomy, University of Turku, Turku, Finland, 2Department
of Orthopaedics, Lund University, Malmö, Sweden |
|
| 09:36 |
OC14 |
PARENTAL HEIGHT AND CHILDHOOD MILK INTAKE
AT 4 YEARS ARE ASSOCIATED WITH CATCH UP BONE MINERAL ACCRUAL IN EARLY
CHILDHOOD
N. C. Harvey*1, M. K. Javaid1, Z. A. Cole1,
S. M. Robinson1, S. R. Crozier1, H. M. Inskip1,
K. M. Godfrey1, E. M. Dennison1, C. Cooper1
1MRC ERC, University of Southampton, Southampton, United
Kingdom |
|
| 09:48 |
OC15 |
VERTEBRAL FRACTURES ARE ASSOCIATED WITH
INCREASED CORTICAL POROSITY IN MALES WITH IDIOPATHIC OSTEOPOROSIS
A. Ostertag1, M. Cohen-Solal1, C. Marty1,
D. Chappard2, M. de Vernejoul*1
1INSERM
U606, Lariboisière Hospital, Paris, 2INSERM E335,
Angers Hospital, Angers, France |
|
15:15-
16:15 |
|
Oral Communications
4: Osteoclasts and Bone Resorption
Chairs: Pedro Esbrit (Madrid, Spain)
Anna Teti (L’Aquila, Italy) |
|
|
| 15:15 |
OC16 |
REGULATION OF T CELL FUNCTION BY OSTEOCLASTS
F. Grassi*1, K. Codeluppi1, C. Manferdini1,
A. Facchini1, G. Lisignoli1
1Laboratorio
di Immunologia e Genetica, Istituti Ortopedici Rizzoli, Bologna, Italy
|
|
| 15:27 |
OC17 |
HIGH BONE MASS AND DECREASED OSTEOCLASTOGENESIS IN MICE
NULL FOR INTERLEUKIN-15 RECEPTOR
S. Ferrari-Lacraz*1, S. Djaafar1, D. Pierroz2,
S. L. Ferrari2
1Division of Immunology and
Transplantation, 2Division of Bone Diseases, Geneva University
Hospital, Geneva, Switzerland |
|
| 15:39 |
OC18 |
CANNABINOID RECEPTOR ANTAGONISTS INHIBIT OSTEOCLAST
FORMATION IN VITRO AND OVARIECTOMY-INDUCED BONE LOSS IN VIVO THROUGH
THE CB1 AND CB2 RECEPTORS
A. Sophocleous*1, E. Landao-Bassonga1, R. van't
Hof1, S. H. Ralston1, A. I. Idris1
1Rheumatology Unit, University of Edinburgh, Edinburgh,
United Kingdom |
|
| 15:51 |
OC19 |
TRANSCRIPTION FACTOR CCAAT/ENHANCER BINDING PROTEIN
(C/EBP) BETA ISOFORM RATIO REGULATES OSTEOCLASTOGENESIS AND BONE HOMEOSTASIS
J. J. Smink*1, V. Begay1, T. Schoenmaker2,
E. Sterneck3, T. J. de Vries2, A. Leutz1
1Tumorigenesis and Cell Differentiation, Max Delbrueck
Center for Molecular Medicine, Berlin, Germany, 2Periodontology
and Oral Cell Biology, Academic Centre of Dentistry Amsterdam, Universiteit
van Amsterdam and Vrije Universiteit, Amsterdam, Netherlands, 3Laboratory
of Cell and Developmental Signaling, National Cancer Institute, Center
for Cancer Research, Frederick, United States |
|
| 16:03 |
OC20 |
SMALL MOLECULE INHIBITORS OF IKK-DEPENDENT
SIGNALLING INHIBIT OSTEOCLAST FORMATION IN VITRO AND OVARIECTOMY-INDUCED
BONE LOSS IN VIVO
A. I. Idris*1, P. Simic2, M. Krishnan1,
S. Vikicevic2, S. H. Ralston1
1Rheumatology,
University of Edinburgh, Edinburgh, United Kingdom, 2Department
of Anatomy, University of Zagreb, Zagreb, Croatia |
|
| Tuesday 27 May, 2008 |
|
09:00-
10:00 |
|
Oral
Communications 5: Hormones and Bone
Chairs: Luis Perez Edo (Barcelona, Spain)
Slobodan Vukicevic (Zagreb, Croatia) |
|
| 09:00 |
OC21 |
DIFFERENTIAL EXPRESSION OF PERIOSTIN AND
TISSUE PLASMINOGEN ACTIVATOR BY MORPHOLOGICALLY DIVERSE HYPERTROPHIC
CHONDROCYTE POPULATIONS
K. S. Chen1, L. Tatarczuch1, Y. Ahmed1,
M. Mirams1, C. N. Pagel1, E. J. Mackie*1
1School of Veterinary Science, University of Melbourne,
Parkville, Australia |
|
| 09:12 |
OC22 |
HOXA2 MISEXPRESSION IN CHONDROCYTES IMPAIRS
THE CELL PROLIFERATION-TO-DIFFERENTIATION CHONDROGENIC SWITCH
P. Deprez*1, C. Nyssen-Behets1, B. Lengelé1,
R. Rezsöhazy2
1Experimental Morphology,
Université catholique de Louvain, Brussels, 2Veterinary
Sciences, Université catholique de Louvain, Louvain-la-Neuve,
Belgium |
|
| 09:24 |
OC23 |
THE MATRIX PROLINE/ARGININE-RICH END LEUCINE-RICH
REPEAT PROTEIN (PRELP) INHIBITS OSTEOCLASTOGENESIS INACTIVATING NF-KAPPAB
SIGNAL.
N. Rucci*1, M. Alamanou1, A. Rufo1,
M. Capulli1, D. Heinegard2, A. Teti1
1Department of Experimental Medicine, University of L'Aquila,
L'Aquila, Italy, 2Department of Experimental Medical Science,
Lund University, Lund, Sweden |
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| 09:36 |
OC24 |
1,25-DIHYDROXYVITAMIN D3 MODULATES DEXAMETHASONE
EFFECTS BY CHANGING TH1/TH17 AND TH2 CYTOKINE PRODUCTION BY PERIPHERAL
BLOOD MONONUCLEAR CELLS IN EARLY RHEUMATOID ARTHRITIS PATIENTS
E. M. Colin*1, P. Asmawidjaja1, M. van Driel2,
J. M. W. Hazes1, J. P. T. M. van Leeuwen2, E.
Lubberts1
1Rheumatology, 2Internal
Medicine, Erasmus MC, Rotterdam, Netherlands |
|
| 09:48 |
OC25 |
THE P38 MAP KINASE PATHWAY PLAYS AN ESSENTIAL
ROLE IN MEDIATING TRABECULAR BONE LOSS INDUCED BY ESTROGEN DEFICIENCY
J. Caverzasio*1, P. Ammann2
1Dept
of Rehabilitation and Geriatrics, 2Rehabilitation and Geriatrics,
Service of Bone Diseases, Geneva, Switzerland |
|
15:05-
16:05
|
|
Oral
Communications 6: Metabolic Bone Disease
Chairs: Joseph Caversazio (Geneva, Switzerland)
Jose Ramon Perez-Cano (Seville, Spain) |
|
| 15:05 |
OC26 |
COOPERATIVITY BETWEEN THE C-FOS PROTO-ONCOGENE
AND FGF RECEPTOR SIGNALLING IN THE PATHOGENESIS OF BONE AND CARTILAGE
TUMOURS
D. B. Weekes*1, D. P. Thomas1, A. Sunters1,
T. G. Kashima1, A. E. Grigoriadis1
1Dept
of Craniofacial Development, King's College London, London, United
Kingdom |
|
| 15:17 |
OC27 |
KNOCK-IN OF THE P392L MUTATION OF SQSTM1
CAUSES A PHENOTYPE SIMILAR TO PAGET’S DISEASE IN MICE
A. Daroszewska*1, J. Rojas1, L. Rose1,
R. J. Van't Hof1, S. H. Ralston1
1Molecular
Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom
|
|
| 15:29 |
OC28 |
DIETARY CALCIUM DEFICIENCY INCREASES OSTEOLYSIS
AND MODIFIES GENE EXPRESSION PROFILE IN AN ANIMAL MODEL OF MULTIPLE
MYELOMA
H. Libouban*1, M. A. Le Drévo1, M. F.
Moreau1, M. F. Baslé1, D. Chappard1
1INSERM, U922, Faculte de Medecine, ANGERS, France |
|
| 15:41 |
OC29 |
GENDER-SPECIFIC CONTROL OF PEAK BONE MASS
BY THE WNT PATHWAY: ANDROGEN SIGNALING PROTECTS AGAINST LEF1 HAPLOINSUFFICIENCY-INDUCED
BONE LOSS
T. J. Noh*1, Y. Gabet1, J. Cogan2,
A. Tank1, T. Sasaki3, B. Criswell2,
A. Dixon2, J. Tam4, T. Kohler5, E.
Regev4, L. Kockeritz6, J. Woodgett6,
R. Müller5, Y. Chai3, E. Smith2,
I. Bab4, B. Frenkel7
1Biochemistry
and Molecular Biology, 2Institute for Genetic Medicine,
3Center for Craniofacial Molecular Biology, University
of Southern California, Los Angeles, United States, 4Bone
Laboratory, The Hebrew University of Jerusalem, Jerusalem, Israel,
5Institute for Biomechanics, ETH Zurich, Zurich, Switzerland,
6Ontario Cancer Institute, Princess Margaret Hospital,
Toronto, Canada, 7Orthopaedic Surgery, University of Southern
California, Los Angeles, United States |
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| 15:53 |
OC30 |
ROLE OF THE TRANSCRIPTION FACTOR RUNX2
AS A MEDIATOR OF THE ANTI-APOPTOTIC EFFECTS OF PARATHYROID HORMONE
(PTH)-RELATED PROTEIN (PTHrP) IN THE DAMAGED KIDNEY
J. A. Ardura*1, V. Alonso1, I. Andrade1,
D. Rámila1, P. Esbrit1
1Bone
and Mineral Metabolism Laboratory, Fundación Jiménez
Díaz, Madrid, Spain |
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16:30-
17:30 |
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Oral Communications
7: Osteoblasts and Bone Formation
Chairs: Concepción de la Piedra (Madrid, Spain)
Pierre Marie (Paris, France)
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|
| 16:30 |
OC31 |
LOSS OF FUNCTION ALPHA10BETA1 MICE EXHIBIT REDUCED
BONE VOLUME
R. S. Collinson*1, T. Bengtsson2, E. Lundgren-Akerlund2,
A. A. Pitsillides1
1Department of VBS, Royal
Veterinary College, London, United Kingdom, 2, Cartela
AB, Lund, Sweden |
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| 16:42 |
OC32 |
TGF2 BETA PREVENTS OSTEOBLAST APOPTOSIS INDUCED BY
SKELETAL UNLOADING BY UPREGULATING ALPHA5/BETA1/PI3K/AKT SIGNALING
IN VIVO
C. Dufour*1, X. Holy2, P. J. Marie1
1Inserm U606 and University Paris 7, Hopital Lariboisiere,
Paris Cedex 10, 2Dept of Integrated Physiology, IMASSA,
Bretigny sur Orge, France |
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| 16:54 |
OC33 |
ZFP521, AN ANTAGONIST TO RUNX2 AND EBF1 TRANSCRIPTIONAL
ACTIVITY, FAVORS BONE FORMATION IN VIVO AND INHIBITS MINERALIZATION
IN VITRO
R. Kiviranta*1, H. Saito1, D. Correa1,
L. Neff1, G. Rowe1, S. Warming2,
N. A. Jenkins3, W. C. Horne1, N. G. Copeland3,
R. Baron1
1Oral Medicine, Infection and
Immunity, Harvard School of Dental Medicine, Boston, 2Molecular
Biology, Genentech, San Fransisco, United States, 3Cancer
Genetics Laboratory, Institute of Molecular and Cell Biology, Singapore,
Singapore |
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| 17:06 |
OC34 |
HISTAMINE PROMOTES OSTEOCLASTOGENESIS THROUGH DIFFERENTIAL
EXPRESSION OF HISTAMINE RECEPTORS ON OSTEOCLAST AND OSTEOBLAST
M. Biosse Duplan*1, B. Baroukh1, M. Dy2,
M. de Vernejoul3, J. Saffar1
1EA
2496, Université Paris Descartes, Montrouge, 2UMR
8147, Université Paris Descartes, 3U606, INSERM,
Paris, France |
|
| 17:18 |
OC35 |
N-CADHERIN-LRP5 INTERACTION NEGATIVELY
CONTROLS OSTEOBLAST PROLIFERATION BY ANTAGONIZING WNT CANONICAL AND
NON-CANONICAL ERK MAPK AND PI3K/AKT SIGNALING PATHWAYS
E. Hay*1, A. Nouraud1, P. J. Marie1
1Inserm U606 and University Paris 7, Hopital Lariboisiere,
Paris Cedex 10, France |
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