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Meet the Professor Lorenz Hofbauer The RANKL/RANK/OPG system in health and disease Outline of topics I will focus first on the discovery as well as cellular and molecular functions of RANKL, RANK, and OPG in bone cell biology. The phenotypes of mice with deletions or transgenes will be discussed. Next, we will discuss animal models of human diseases (osteoporosis, bone metastastases, arthritis), and the role of RANKL in maintaining them. The potential of RANKL blockade will also discussed. We will also include a section on non-skeletal effects (vascular, immune) of this system. Finally, human diseases with alterations of the RANKL/OPG balance as well as the existing data of RANKL blockade by denosumab to treat bone loss in humans will be discussed. Educational goals
Target Audience
Teaching methods I will give a brief introduction and then we will
start Q & A. The audience is specifically asked to discuss their view
of this field. Problems with ongoing research (basic science, OPG/RANKL
measurement, animal studies) projects will be discussed in an open and
friendly fashion.
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